Map - Woodruff County, Arkansas (Woodruff County)

Woodruff County is located in the Arkansas Delta in the U.S. state of Arkansas. The county is named for William E. Woodruff, founder of the state's first newspaper, the Arkansas Gazette. Created as Arkansas's 54th county in 1862, Woodruff County is home to one incorporated town and four incorporated cities, including Augusta, the county seat. The county is also the site of numerous unincorporated communities and ghost towns. Occupying only 587 sqmi, Woodruff County is the 13th smallest county in Arkansas. As of the 2020 Census, the county's population was 6,269. Based on population, the county is the second-smallest county of the 75 in Arkansas. Located in the Arkansas Delta, the county is largely flat with fertile soils. Historically covered in forest, bayous and swamps, the area was cleared for agriculture by early settlers. It is drained by the Cache River and the White River. Along the Cache River, the Cache River National Wildlife Refuge (NWR) runs north–south across the county, preserving bottomland forest, sloughs and wildlife habitat.

Although no Interstate highways are located in Woodruff County, two United States highways (US 49 and US 64) and twelve Arkansas state highways run in the county. Two Union Pacific Railroad lines cross the county.

The county is located in the Arkansas Delta, one of the six primary geographic regions of Arkansas. The Arkansas Delta is a subregion of the Mississippi Alluvial Plain, which is a flat area consisting of rich, fertile sediment deposits from the Mississippi River between Louisiana and Illinois. According to the U.S. Census Bureau, the county has a total area of 594 sqmi, of which 587 sqmi is land and 7.2 sqmi (1.2%) is water. Major hydrologic features include the Cache River, which roughly bisects the county north–south, Bayou De View, which runs through eastern Woodruff County, and the White River, which serves as the county's western boundary.

Prior to settlement, Woodruff County was densely forested, with bayous, sloughs, and swamps crossing the land. Seeking to take advantage of the area's fertile soils, settlers cleared the land to better suit row crops. Although some swampland has been preserved in the Cache River NWR and some former farmland has undergone reforestation, the majority (56 percent) of the county remains in cultivation. Another large land use in Woodruff County is the Cache River NWR, owned by the United States Fish and Wildlife Service. Stretching approximately 90 mi across adjacent counties, the NWR is listed as a Ramsar wetlands of international importance, and serves as a key wintering area for ducks and the largest contiguous tract of bottomland hardwood forest in North America. The NWR aggressively seeks willing property owners to sell land to add to the NWR's boundaries, adding 2000 acre in 2015.

The county is located approximately 75 mi northeast of Little Rock and 81.3 mi west of Memphis, Tennessee. Woodruff County is surrounded by five other Delta counties: Jackson County to the north, Cross County to the northeast, St. Francis County to the southeast, Monroe County to the south and Prairie County to the southwest. West of Woodruff County is White County, which is something of combination point for the Delta, Ozarks, and Central Arkansas.